| Absorption | The absolute bioavailability of acamprosate after oral administration is about 11%. The food effect on absorption is not clinically significant and no adjustment of dose is necessary. |
| Volume of distribution |
|
| Protein binding | Non detectable |
| Metabolism | Acamprosate does not undergo metabolism. |
| Route of elimination | Following oral administration of CAMPRAL®, the major route of excretion is via the kidneys as acamprosate. |
| Half life | 20 - 33 hours |
| Clearance | Not Available |
| Toxicity | In all reported cases of acute overdosage with acamprosate (total reported doses of up to 56 grams of acamprosate calcium), the only symptom that could be reasonably associated with acamprosate was diarrhea. |
| Affected organisms |
|
| Pathways | Not Available |
Acamprosate
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