Acebutolol

Absorption	Well absorbed from the Gl tract with an absolute bioavailability of approximately 40% for the parent compound. In
Volume of distribution	Not Available
Protein binding	26%
Metabolism	Subject to extensive first-pass hepatic biotransformation (primarily to diacetolol).
Route of elimination	Elimination via renal excretion is approximately 30% to 40% and by non-renal mechanisms 50% to 60%, which includes excretion into the bile and direct passage through the intestinal wall.
Half life	The plasma elimination half-life is approximately 3 to 4 hours. The half-life of its metabolite, diacetolol, is 8 to 13 hours.
Clearance	Not Available
Toxicity	Symptoms of overdose include extreme bradycardia, advanced atrioventricular block, intraventricular conduction defects, hypotension, severe congestive heart failure, seizures, and in susceptible patients, bronchospasm, and hypoglycemia.
Affected organisms	Humans and other mammals
Pathways	Pathway Name Acebutolol Pathway