| Absorption | Rapidly absorbed from the GI tract. |
| Volume of distribution | Not Available |
| Protein binding | 90% |
| Metabolism | Extensively metabolized in the liver to the active metabolite hydroxyhexamide, which exhibits greater hypoglycemic potency than acetohexamide. Hydroxyhexamide is believed to be responsible for prolonged hypoglycemic effects. |
| Route of elimination | Not Available |
| Half life | Elimination half-life of the parent compound is 1.3 hours and the elimination half-life of the active metabolite is approximately 5-6 hours. |
| Clearance | Not Available |
| Toxicity | Oral, rat LD50: 5 gm/kg; Oral, mouse LD50: >2500 mg/kg. Symptoms of an acetohexamide overdose include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma. |
| Affected organisms |
|
| Pathways | Not Available |
Acetohexamide
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