| Absorption | Bioavailability is 6–10% following oral administration and less than 3% following topical administration. |
| Volume of distribution | Not Available |
| Protein binding | 83% |
| Metabolism | Hepatic. Deacetylated by the liver to cysteine and subsequently metabolized. |
| Route of elimination | Not Available |
| Half life | 5.6 hours (adults), 11 hours (neonates) |
| Clearance | Not Available |
| Toxicity | Single intravenous doses of acetylcysteine at 1000 mg/kg in mice, 2445 mg/kg in rats, 1500 mg/kg in guinea pigs, 1200 mg/kg in rabbits and 500 mg/kg in dogs were lethal. Symptoms of acute toxicity were ataxia, hypoactivity, labored respiration, cyanosis, loss of righting reflex and convulsions. |
| Affected organisms |
|
| Pathways | Not Available |
Acetylcysteine
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