| Absorption | Oral: bioavailability 10 to 20% |
| Volume of distribution | Not Available |
| Protein binding | 9%-33% |
| Metabolism | Hepatic, the only major urinary metabolite that has been detected is 9-carboxymethoxymethylguanine. |
| Route of elimination | Acyclovir is cleared renally. |
| Half life | 2.5-3.3 hours |
| Clearance | Not Available |
| Toxicity | Aciclovir may cause nephrotoxicity (crystallization of aciclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of aciclovir therapy. However, there is no well-defined relationship between aciclovir concentrations in the blood and these adverse effects. |
| Affected organisms |
|
| Pathways | Not Available |
Aciclovir
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