| Absorption | Absorption of adapalene through human skin is low. Only trace amounts (<0.25 ng/mL) of parent substance have been found in the plasma of acne patients following chronic topical application of adapalene in controlled clinical trials |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism | Metabolized mainly by O-demethylation, hydroxylation and conjugation, and excretion is primarily by the biliary route. |
| Route of elimination | Excretion appears to be primarily by the biliary route. |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | The acute oral toxicity of adapalene in mice and rats is greater than 10 mL/kg. Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A. |
| Affected organisms |
|
| Pathways | Not Available |
Adapalene
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