Alcaftadine

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Absorption Not Available
Volume of distribution Not Available
Protein binding The protein binding of alcaftadine and the active metabolite are 39.2% and 62.7% respectively.
Metabolism
The metabolism of alcaftadine is mediated by non-CYP450 cytosolic enzymes to the active carboxylic acid metabolite.
Route of elimination Based on data following oral administration of alcaftadine, the carboxylic acid metabolite is primarily eliminated unchanged in the urine.
Half life The elimination half-life of the carboxylic acid metabolite is approximately 2 hours following topical ocular administration.
Clearance Not Available
Toxicity Not Available
Affected organisms Not Available
Pathways Not Available

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