Alfuzosin

Absorption	Absorption is 50% lower under fasting conditions
Volume of distribution	3.2 L/kg [healthy male middle-aged volunteers]
Protein binding	82%-90%
Metabolism	Hepatic. Alfuzosin undergoes extensive metabolism by the liver, with only 11% of the administered dose excreted unchanged in the urine. Alfuzosin is metabolized by three metabolic pathways: oxidation, O-demethylations, and N-dealkylation. The metabolites are not pharmacologically active. CYP3A4 is the principal hepatic enzyme isoform involved in its metabolism.
Route of elimination	Following oral administration of 14C-labeled alfuzosin solution, the recovery of radioactivity after 7 days (expressed as a percentage of the administered dose) was 69% in feces and 24% in urine.
Half life	10 hours
Clearance	Not Available
Toxicity	Side effects are dizziness (due to postural hypotension), upper respiratory tract infection, headache, and fatigue.
Affected organisms	Humans and other mammals
Pathways	Not Available