Allopurinol

Absorption	Approximately 80-90% absorbed from the gastrointestinal tract.
Volume of distribution	Not Available
Protein binding	Allopurinol and oxypurinol are not bound to plasma proteins
Metabolism	Hepatic Enzyme Metabolite Reaction Km Vmax Xanthine dehydrogenase/oxidase oxidation Aldehyde oxidase oxypurinol oxidation
Route of elimination	Approximately 20% of the ingested allopurinol is excreted in the feces.
Half life	1-3 hours
Clearance	Not Available
Toxicity	LD50=214 mg/kg (in mice)
Affected organisms	Humans and other mammals
Pathways	Not Available