Almotriptan

Absorption	Not Available
Volume of distribution	180 to 200 L
Protein binding	35%
Metabolism	Enzyme Metabolite Reaction Km Vmax Amine oxidase [flavin-containing] A Oxidative deamination Cytochrome P450 3A4 N-desmethylalmotriptan N-demethylation 434 0.2
Route of elimination	Almotriptan is eliminated primarily by renal excretion (about 75% of the oral dose), with approximately 40% of an administered dose excreted unchanged in urine. Approximately 13% of the administered dose is excreted via feces, both unchanged and metabolized.
Half life	3-4 hours
Clearance	57 L/h [healthy] 34.2 L/h [moderate renal impairment (creatinine clearance between 31 and 71 mL/min)] 9.8 L/h [severe renal impairment (creatinine clearance between 10 and 30 mL/min)]
Toxicity	Not Available
Affected organisms	Humans and other mammals
Pathways	Not Available