Alvimopan

Absorption	Alvimopan's high affinity for the peripheral mu-receptor results in an absolute oral bioavailability of less than 7%.
Volume of distribution	30±10 L
Protein binding	80% to 90% of systemically available alvimopan is bound to plasma protein.
Metabolism	Alvimopan undergoes no significant hepatic metabolism, but is metabolized by intestinal flora. Gut metabolism produces an active metabolite with no clinically significant contribution to drug effect.
Route of elimination	Biliary secretion was considered the primary pathway for alvimopan elimination. Unabsorbed drug and unchanged alvimopan resulting from biliary excretion were then hydrolyzed to its ‘metabolite’ by gut microflora.
Half life	10 to 17 hours (gut metabolite: 10 to 18 hours)
Clearance	402 +/- 89 mL/min
Toxicity	Not Available
Affected organisms	Humans and other mammals