| Absorption | Readily absorbed following oral administration. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism | Amiloride is not metabolized by the liver but is excreted unchanged by the kidneys. |
| Route of elimination | Amiloride HCl is not metabolized by the liver but is excreted unchanged by the kidneys. About 50 percent of a 20 mg dose of amiloride HCl is excreted in the urine and 40 percent in the stool within 72 hours. |
| Half life | Plasma half-life varies from 6 to 9 hours. |
| Clearance | Not Available |
| Toxicity | No data are available in regard to overdosage in humans. The oral LD50 of amiloride hydrochloride (calculated as the base) is 56 mg/kg in mice and 36 to 85 mg/kg in rats, depending on the strain. The most likely signs and symptoms to be expected with overdosage are dehydration and electrolyte imbalance. |
| Affected organisms |
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Amiloride
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