Aminocaproic Acid

Absorption	Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Volume of distribution	23.1 ± 6.6 L
Protein binding	Not Available
Metabolism	Sixty-five percent of the dose is recovered in the urine as unchanged drug and 11% of the dose appears as the metabolite adipic acid.
Route of elimination	Renal excretion is the primary route of elimination, whether aminocaproic acid is administered orally or intravenously.
Half life	The terminal elimination half-life is approximately 2 hours.
Clearance	169 mL/min
Toxicity	A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Affected organisms	Humans and other mammals