| Absorption | Amlodipine is slowly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached 6-12 hour following oral administration. Its estimated bioavailability is 64-90%. Absorption is not affected by food. |
| Volume of distribution | Not Available |
| Protein binding | 97.5% |
| Metabolism | Hepatic. Metabolized extensively (90%) to inactive metabolites via the cytochrome P450 3A4 isozyme. |
| Route of elimination | Amlodipine is extensively (about 90%) converted to inactive metabolites via hepatic metabolism with 10% of the parent compound and 60% of the metabolites excreted in the urine. |
| Half life | 30-50 hours |
| Clearance | Not Available |
| Toxicity | Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported. |
| Affected organisms |
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Amlodipine
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