Amodiaquine

Absorption	Rapidly absorbed following oral administration.
Volume of distribution	Not Available
Protein binding	Not Available
Metabolism	Hepatic biotransformation to desethylamodiaquine (the principal biologically active metabolite) is the predominant route of amodiaquine clearance with such a considerable first pass effect that very little orally administered amodiaquine escapes untransformed into the systemic circulation. Enzyme Metabolite Reaction Km Vmax Cytochrome P450 2C8 desethylamodiaquine N-deethylation 2000 0
Route of elimination	Not Available
Half life	5.2 ± 1.7 (range 0.4 to 5.5) minutes
Clearance	Not Available
Toxicity	LD50 (mouse, intraperitoneal) 225 mg/kg, LD50 (mouse, oral) 550 mg/kg. Symptoms of overdose include headache, drowsiness, visual disturbances, vomiting, hypokalaemia, cardiovascular collapse and cardiac and respiratory arrest. Hypotension, if not treated, may progress rapidly to shock. Electrocardiograms (ECG) may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, broadening of the QRS complex, and progressive bradycardia leading to ventricular fibrillation and/or arrest.
Affected organisms	Plasmodium