Amoxicillin

Absorption	Rapidly absorbed after oral administration.
Volume of distribution	Not Available
Protein binding	In blood serum, amoxicillin is approximately 20% protein-bound
Metabolism	Hepatic metabolism accounts for less than 30% of the biotransformation of most penicillins
Route of elimination	Most of the amoxicillin is excreted unchanged in the urine; its excretion can be delayed by concurrent administration of probenecid.
Half life	61.3 minutes
Clearance	Not Available
Toxicity	Serious toxicity is unlikely following large doses of amoxicillin. Acute ingestion of large doses of amoxicillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses.
Affected organisms	Enteric bacteria and other eubacteria