| Absorption | Rapidly absorbed after oral administration in HIV-1-infected patients with a time to peak concentration (Tmax) typically between 1 and 2 hours after a single oral dose. The absolute oral bioavailability of amprenavir in humans has not been established. |
| Volume of distribution | Not Available |
| Protein binding | Very high (90%). Amprenavir has the highest affinity for alpha(1)-acid glycoprotein. |
| Metabolism | Hepatic. Amprenavir is metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system. The 2 major metabolites result from oxidation of the tetrahydrofuran and aniline moieties. Glucuronide conjugates of oxidized metabolites have been identified as minor metabolites in urine and feces. |
| Route of elimination | Not Available |
| Half life | 7.1-10.6 hours |
| Clearance | Not Available |
| Toxicity | Not Available |
| Affected organisms |
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Amprenavir
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