Anastrozole

Absorption	Rapidly absorbed into the systemic cirulation following oral administration. Peak plasma concentrations are usually attained within 2 hours under fasting conditions, with steady-state plasma concentrations attained in approximately 7 days.
Volume of distribution	Not Available
Protein binding	40%
Metabolism	Hepatic. Metabolized mainly by N-dealkylation, hydroxylation, and glucuronidation to inactive metabolites. Primary metabolite is an inactive triazole.
Route of elimination	Hepatic metabolism accounts for approximately 85% of anastrozole elimination. Renal elimination accounts for approximately 10% of total clearance.
Half life	50 hours
Clearance	Not Available
Toxicity	In rats, lethality is greater than 100 mg/kg.
Affected organisms	Humans and other mammals