| Absorption | Aminoglycosides are not well absorbed from the gastrointestinal tract. Their absorption is markedly improved by parenteral administration. |
| Volume of distribution | Not Available |
| Protein binding | 3-12% |
| Metabolism | |
| Route of elimination | Not Available |
| Half life | 3 hours |
| Clearance | Not Available |
| Toxicity | Ototoxicity and nephrotoxicity are the most serious adverse effects of aminoglycoside therapy and are more likely to occur in patients with a history of renal impairment or who are receiving other ototoxic and/or nephrotoxic drugs. Normal duration of IM or IV aminoglycoside therapy is 7-10 days. Although a longer duration may be necessary in some cases, toxicity is more likely to occur when aminoglycoside treatment is continued for longer than 10 days. |
| Affected organisms |
|
Arbekacin
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