Argatroban

Absorption	Bioavailability is 100% (intravenous).
Volume of distribution	174 mL/kg 12.18 L [70-kg adult]
Protein binding	54%
Metabolism	Liver via hydroxylation and aromatization of the 3-methyltetrahydroquinoline ring. Age and gender do not substantially affect the pharmacodynamic or pharmacokinetic profile of argatroban.
Route of elimination	Argatroban is excreted primarily in the feces (65%), presumably through biliary secretion; 22% is eliminated via urine.
Half life	39 and 51 minutes
Clearance	5.1 L/kg/hr [infusion doses up to 40 mcg/kg/min]
Toxicity	Excessive bleeding
Affected organisms	Humans and other mammals