| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | 75% bound |
| Metabolism | The metabolism of arsenic trioxide involves reduction of pentavalent arsenic to trivalent arsenic by arsenate reductase and methylation of trivalent arsenic to monomethylarsonic acid and monomethylarsonic acid to dimethylarsinic acid by methyltransferases. The main site of methylation reactions appears to be the liver. Arsenic is stored mainly in liver, kidney, heart, lung, hair and nails. |
| Route of elimination | Trivalent arsenic is mostly methylated in humans and excreted in urine. |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Symptoms of overdose include convulsions, muscle weakness and confusion. |
| Affected organisms |
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Arsenic trioxide
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