Astemizole

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Absorption Rapidly absorbed from the gastrointestinal tract.
Volume of distribution Not Available
Protein binding 96.7%
Metabolism
Almost completely metabolized in the liver and primarily excreted in the feces.
Enzyme Metabolite Reaction Km Vmax
Cytochrome P450 3A4 desmethylastemizole O-demethylation 10 191.82
Route of elimination Not Available
Half life 1 day
Clearance Not Available
Toxicity LD50=2052mg/kg in mice
Affected organisms
  • Humans and other mammals

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