| Absorption | Approximately 4% of the topically applied azelaic acid is systemically absorbed. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism | Mainly excreted unchanged in the urine but undergoes some b-oxidation to shorter chain dicarboxylic acids. |
| Route of elimination | Azelaic acid is mainly excreted unchanged in the urine, but undergoes some ß-oxidation to shorter chain dicarboxylic acids. |
| Half life | The observed half-lives in healthy subjects are approximately 45 minutes after oral dosing and 12 hours after topical dosing, indicating percutaneous absorption rate-limited kinetics. |
| Clearance | Not Available |
| Toxicity | Oral LD50 in rat: >5 g/kg |
| Affected organisms |
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Azelaic Acid
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